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Related Experiment Video

Updated: Jun 17, 2026

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Published on: September 20, 2019

Chemokines.

Andreas Hippe¹, Bernhard Homey, Anja Mueller-Homey

¹Department of Dermatology, Heinrich-Heine-University, Düsseldorf, Germany. ahippe@gmail.com

Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer

|December 25, 2009

Summary

This summary is machine-generated.

Tumors need new blood vessels for growth, a process called tumor neo-angiogenesis. This review explores how chemokines, a type of signaling molecule, influence this critical process in cancer.

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Last Updated: Jun 17, 2026

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

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Published on: September 20, 2019

Rapid and Robust Analysis of Cellular and Molecular Polarization Induced by Chemokine Signaling

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Published on: December 12, 2014

Live Imaging of Chemokine Receptors in Zebrafish Neutrophils During Wound Responses

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Published on: December 4, 2020

Area of Science:

Oncology
Molecular Biology
Biochemistry

Background:

Tumor growth beyond 2 micrometers requires nutrient and oxygen supply via new blood vessels.
Tumor neo-angiogenesis is a complex process involving tumor-vasculature interactions.
Tumor vasculature supports growth and facilitates metastasis.

Purpose of the Study:

To review the role of chemokines in tumor-associated angiogenesis.
To elucidate the mechanisms by which chemokines regulate blood vessel formation in tumors.

Main Methods:

Literature review of studies on chemokines and angiogenesis.
Analysis of research on chemokine involvement in homeostatic and neoplastic angiogenesis.

Main Results:

Chemokines are key mediators in tumor angiogenesis.
These molecules create a pro-angiogenic microenvironment.
Chemokines contribute to both tumor growth and metastasis via vascular networks.

Conclusions:

Chemokines play a significant role in tumor neo-angiogenesis.
Targeting chemokines may offer therapeutic strategies for cancer.
Understanding chemokine function is crucial for developing anti-angiogenic therapies.