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Related Experiment Video

Updated: Jun 17, 2026

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

Caveolae and cancer.

Kerri A Massey¹, Jan E Schnitzer

¹Sidney Kimmel Cancer Center, San, Diego, Ca 92121, USA.

Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer

|December 25, 2009

Summary

Targeting caveolae, which are transport vesicles on endothelial cells, may offer a universal method for delivering drugs and therapies directly into specific tissues, including tumors. This approach enhances therapeutic efficacy and reduces side effects by concentrating treatments where needed.

Area of Science:

Vascular Biology
Cellular Transport
Oncology

Background:

Endothelial cells line blood vessels, regulating permeability.
Caveolae are transport vesicles on endothelial cells facilitating molecular transport.
Tissue-specific proteins on vasculature can be targeted for drug delivery.

Purpose of the Study:

To explore targeting caveolae for enhanced drug delivery into specific tissues.
To investigate the potential of caveolae as a universal portal for therapeutic agents.

Main Methods:

Identifying tissue-specific proteins on vascular endothelial cells.
Utilizing antibodies to target these proteins concentrated in caveolae.
Investigating the transport of molecules into and across the endothelium via caveolae.

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Published on: June 26, 2019

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Last Updated: Jun 17, 2026

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

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Published on: September 20, 2016

Screening Ion Channels in Cancer Cells

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Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis

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Published on: June 26, 2019

Main Results:

Targeting tumor vasculature proteins with antibodies can destroy tumors and improve survival.
Caveolae facilitate the rapid transport of molecules into tissues.
Tumor-specific proteins are present on the surface of tumor vasculature.

Conclusions:

Targeting caveolae may provide a universal mechanism for delivering drugs, imaging agents, and gene vectors into tissues.
This strategy holds promise for increasing therapeutic efficacy and reducing side effects in cancer treatment.
Further research into caveolae-mediated transport could revolutionize targeted therapies.