Outcome of severe preeclampsia manifested as nephrotic syndrome

To discuss the clinical features of severe preeclampsia and its outcome manifested as nephrotic syndrome (NSP).

Clinical data of 22 NSP patients treated in our hospital from January 2003 to March 2008 were collected to retrospectively analyze the blood pressure, serum albumin, urea nitrogen, cholesterol, 24 h urine protein, etc. before and after pregnancy.

(1) The outcome of pregnant women: the blood pressure of patients in all 22 cases recovered within 6 weeks; edema usually regressed within 6 weeks, however, only 1 patient recovered on week 10; urine protein usually disappeared within 6 weeks, however, it kept remaining in the urine of patients in 2 cases after 10 weeks; the recovery of blood lipid, serum uric acid and plasma albumin often occurred within 4-10 weeks, while only a few patients did not recover; no pregnant woman died, indicating good prognosis. (2) The outcome of perinatal infant: 7 perinatal infants died (31.8%), and 9 neonatal infants were asphyxiated (40.9%), and 15 neonatal infants with low weight were born (68.2%).

All indexes of NSP patients usually recovered within 6 weeks after pregnancy cessation.