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Published on: April 1, 2015
[Protecting effect of Chaenomeles speciosa broth on immunosuppressive mice induced by cyclophosphamide]
Ji-jing Shi1, Chao-qi Liu, Bin Li
1Institute of Molecular Biology, China Three Gorges University, Yichang 443002, China. annashijijing@yahoo.com
Objective:
To investigate the effects of Chaenomeles speciosa broth on immunoregulation for anti-tumor chemotherapy.
Methods:
Immunosuppressive model was induced by cyclophosphamide (CTX) in mice. The mice were treated with the broth for 15 days. The serum hemolysin was observed in mouse sera. Spleen lymphocyte transformation and gene transcription related to the immunoregulation in spleen lymphocytes were detected.
Results:
After administrated the broth, the serum hemolysin and lymphocyte transformation rates significantly increased and the mRNA expression of foxp3, TGF-beta, PD1, Fas, Bax were downregulated compared with CTX-group.
Conclusion:
Chaenomeles speciosa broth has protective effects on the immunosuppressive mouse induce by CTX.