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Updated: Jun 17, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Polysynovitis after oligofructose overload in dairy cattle.

A M Danscher¹, H L Enemark, P H Andersen

¹Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark. amd@life.ku.dk

Journal of Comparative Pathology

|December 26, 2009

Summary

Oligofructose overload in dairy heifers caused sterile inflammation in synovial joints, leading to lameness and joint distension. This finding offers new insights into the complex pathogenesis of bovine laminitis.

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Last Updated: Jun 17, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Area of Science:

Veterinary Medicine
Animal Science
Pathology

Background:

Acute bovine laminitis is a systemic disease affecting claws.
Oligofructose overload has been linked to tarsocrural joint distension in heifers.
The precise pathogenesis of bovine laminitis requires further investigation.

Purpose of the Study:

To investigate the effects of oligofructose overload on bovine synovial joints and tendon sheaths.
To characterize the inflammatory response in synovial fluid and membranes.
To elucidate the role of joint inflammation in oligofructose-induced laminitis.

Main Methods:

Oral oligofructose overload administered to ten dairy heifers.
Clinical examination including locomotion scoring and joint palpation.
Analysis of synovial fluid (protein, WBC count) and synovial membrane histology.
Bacteriological culture of synovial fluid.

Main Results:

Oligofructose overload induced ruminal and systemic acidosis.
Lameness and tarsocrural joint distension were observed in overloaded heifers.
Synovial fluid showed increased turbidity, protein, and WBC counts.
Histology revealed sterile neutrophilic polysynovitis, which decreased in severity over time.

Conclusions:

Oligofructose overload causes generalized sterile neutrophilic polysynovitis in dairy heifers.
This inflammatory joint response is a significant component of oligofructose-induced laminitis.
Understanding polysynovitis may provide new perspectives on bovine laminitis pathogenesis.