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Related Experiment Videos

Endocrine function in children with human immunodeficiency virus infection.

L J Schwartz1, Y St Louis, R Wu

  • 1Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10467.

American Journal of Diseases of Children (1960)
|March 1, 1991
PubMed
Summary

Pediatric endocrine dysfunction may contribute to failure to thrive in children with human immunodeficiency virus (HIV). Some patients showed compensated hypothyroidism, a potentially correctable issue.

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Area of Science:

  • Pediatric Endocrinology
  • Infectious Diseases
  • Human Immunodeficiency Virus (HIV) Research

Background:

  • Failure to thrive (FTT) is a concern in pediatric HIV infection.
  • Endocrine dysfunction is a potential, yet understudied, contributor to FTT in this population.

Purpose of the Study:

  • To investigate the role of endocrine dysfunction in explaining failure to thrive (FTT) among pediatric patients with human immunodeficiency virus (HIV).

Main Methods:

  • Endocrine evaluation of 14 HIV-infected pediatric patients with adequate nutritional status.
  • Assessment of growth hormone, cortisol, somatomedin C, and thyroid function (thyrotropin, thyroid-releasing hormone).

Main Results:

  • Adequate growth hormone and cortisol responses were observed.

Related Experiment Videos

  • Low somatomedin C levels were found in 8 of 12 subjects.
  • 36% (5/14) of patients exhibited elevated thyrotropin levels, indicating compensated hypothyroidism despite normal thyroid function.

    • Conclusions:

    • Subtle thyroid regulation alterations, specifically compensated hypothyroidism, may contribute to FTT in some pediatric HIV patients.
    • These endocrine findings represent a potentially correctable factor in managing FTT in this cohort.