Related Experiment Video
Updated: Jun 17, 2026
Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
[Dynamic changes of plasma tissue factor and tissue factor pathway inhibitor-1 and their clinical significance in
Ze-qiang Zhou1, Zhe Deng, Wei-dong Wang
1Department of Emergency Medicine, Shenzhen Second People's Hospital, Shenzhen 518035, China. zhouzeqiang66666@21cn.com
Objective:
To investigate the dynamic changes of plasma tissue factor (TF) and tissue factor pathway inhibitor-1 (TFPI-1) and their significance in patients with multiple traumas.
Methods:
The plasma levels of TF, TFPI-1 and D-dimer were detected using enzyme-linked immunosorbent assay in patients on the first, second and third days after multiple traumas, with 25 healthy adults as the normal control.
Results:
The levels of plasma TF and D-dimer increased on the first day, and reached the peak value on the second day, but TFPI-1 decreased with the passage of time. Significant differences were found in the levels of plasma TF between the multiple trauma patients (on the first, second, third posttrauma days) and the control group (P<0.01). Significant differences were also found in plasma TFPI-1 and D-dimer between the patients (on the second and third posttrauma days) and the control group (P<0.05).
Conclusion:
Coagulation dysfunction and secondary fibrinolysis occur in the early stage of multiple traumas. Dynamic detection of plasma TF, TFPI and D-dimer is beneficial for understanding the degree of diffuse intravascular coagulation and inflammation after the trauma and can be used as the reference indexes for clinical diagnosis and therapy.
Related Concept Videos
01:20Extrinsic and Intrinsic Pathways of Hemostasis
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
01:09Coagulation
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
01:16Clot Retraction and Fibrinolysis
01:25Acute Inflammation III: Local and Systemic Effects
01:22Formation of the Platelet Plug
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...