Isolated recurrence of granulocytic sarcoma-two case reports-

Area of Science:

• Hematology
• Oncology
• Neurosurgery

Background:

• Granulocytic sarcoma, a rare extramedullary tumor of myeloid blasts, can occur in patients with hematologic malignancies.
• Isolated recurrence of granulocytic sarcoma presents unique diagnostic and therapeutic challenges.

Observation:

• Two patients with a history of hematologic neoplasm presented with rare isolated recurrent granulocytic sarcoma.
• One patient had an extra- and intracranial mass 10 years post-bone marrow transplant for chronic myeloid leukemia.
• The other patient had an intracranial mass 3 years after acute myeloid leukemia remission.

Findings:

• Surgical resection followed by radiotherapy and chemotherapy led to complete remission in the first patient.
• The second patient, treated with whole brain radiotherapy alone, experienced treatment failure and died of systemic leukemia.

Implications:

• Neurosurgeons must be vigilant for isolated recurrent granulocytic sarcoma in patients with a history of hematologic neoplasm.
• Timely pathological and cytogenetic diagnosis is essential for effective management.
• Multimodal treatment approaches may improve outcomes for this rare condition.