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Evaluation of left ventricular synchronicity in hypertensive patients with overweight or obesity

Shao-Hua Li1, Hong-Wei Tan, Zhi-Hao Wang

  • 1Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Jinan, China.

Obesity (Silver Spring, Md.)
|December 26, 2009
PubMed

Insights

Hypertension impairs left ventricular synchronicity, with overweight and obesity worsening systolic and diastolic function. Body Mass Index (BMI) is an independent predictor of this decline in hypertensive individuals.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Obesity Medicine

Background:

  • Left ventricular synchronicity is crucial for cardiac function.
  • Hypertension is a common condition associated with cardiovascular complications.
  • The impact of overweight and obesity on left ventricular synchronicity in hypertensive patients requires further investigation.

Purpose of the Study:

  • To evaluate left ventricular systolic and diastolic synchronicity in hypertensive patients with varying Body Mass Index (BMI) levels.
  • To determine if overweight and obesity exacerbate left ventricular synchronicity impairment in hypertension.
  • To identify BMI as a potential predictor of altered left ventricular synchronicity.

Main Methods:

  • Tissue Doppler imaging was utilized in 126 hypertensive patients and 25 controls.
  • Hypertensive patients were stratified into normal weight (BMI <25 kg/m²), overweight (BMI 25-29.9 kg/m²), and obese (BMI ≥30 kg/m²) groups.
  • Left ventricular systolic (T(s)-diff, T(s)-SD) and diastolic (T(e)-diff, T(e)-SD) synchronicity were assessed using time differences and standard deviations between myocardial segments.

Main Results:

  • Hypertensive patients exhibited significantly prolonged indexes of left ventricular synchronicity compared to controls.
  • Impaired systolic and diastolic synchronicity worsened progressively with increasing BMI among hypertensive groups.
  • Body Mass Index (BMI) emerged as an independent predictor for T(s)-SD and T(e)-SD.

Conclusions:

  • Left ventricular synchronicity impairment is aggravated by increasing BMI in hypertensive patients.
  • Overweight and obesity are significant contributing factors to reduced left ventricular synchronicity in hypertension.
  • These findings highlight the importance of weight management in hypertensive individuals to preserve cardiac function.

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