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Recurrent herpes gestationis with postpartum flare: a case report.

L V Baxi¹, O P Kovilam, M H Collins

¹Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.

American Journal of Obstetrics and Gynecology

|March 1, 1991

Summary

Herpes gestationis (HG) can recur in pregnancy, sometimes with placental villitis. While one pregnancy resulted in stillbirth, subsequent pregnancies had favorable outcomes with corticosteroid treatment.

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Area of Science:

Obstetrics
Dermatology
Immunology

Background:

Herpes gestationis (HG), now known as pemphigoid gestationis, is a rare autoimmune blistering disease that occurs during pregnancy.
It is characterized by intense pruritus and polymorphic eruptions, typically starting in the second or third trimester.

Observation:

This case describes a patient with recurrent herpes gestationis in multiple pregnancies.
The patient experienced a postpartum flare-up in her most recent pregnancy.
Diagnosis was histopathologically confirmed via skin biopsy.

Findings:

The first pregnancy resulted in a term stillbirth.
Four subsequent pregnancies had favorable outcomes.
Histopathologic examination of placentas from the last three pregnancies revealed varying grades of villositis.

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Implications:

Herpes gestationis may be associated with adverse pregnancy outcomes, including stillbirth.
Villositis observed in placental examinations suggests a potential link between HG and placental pathology.
Early diagnosis and management, including the use of oral corticosteroids, can lead to favorable pregnancy outcomes.