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Notch signaling in pancreatic endocrine cell and diabetes

Wook Kim1, Yu-Kyong Shin, Byung-Joon Kim

  • 1NIA/NIH, Baltimore, MD 21224, USA.

Biochemical and Biophysical Research Communications
|December 29, 2009
PubMed

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

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