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Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

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Published on: February 18, 2016

Adaptations in medial prefrontal cortex function associated with amphetamine-induced behavioral sensitization.

J M Gulley¹, J J Stanis

¹Department of Psychology and Neuroscience Program, University of Illinois at Urbana-Champaign, 731 Psychology Building MC-716, 603 E Daniel Street, Champaign, IL 61820, USA. jgulley@illinois.edu

|December 29, 2009

Summary

This summary is machine-generated.

Repeated amphetamine (AMPH) exposure causes behavioral sensitization but few changes in medial prefrontal cortex (mPFC) neuronal activity. Adaptations were mainly observed in neurons excited by AMPH, suggesting limited mPFC functional changes.

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Area of Science:

Neuroscience
Psychopharmacology

Background:

Prefrontal cortex (PFC) neuroadaptations are linked to psychostimulant effects.
Limited studies investigate neuronal activity during psychostimulant sensitization development.

Purpose of the Study:

To measure medial prefrontal cortex (mPFC) single neuron activity during amphetamine (AMPH) sensitization.
To correlate behavioral changes with neural activity following repeated AMPH exposure.

Main Methods:

Recorded single neuron activity in male rat mPFC after daily AMPH or saline exposure.
Administered AMPH or saline challenges after withdrawal.
Analyzed baseline and evoked neuronal firing rates.

Main Results:

Locomotor sensitization to AMPH developed and was significant at challenge.
No significant changes in baseline mPFC neuronal activity were observed.
AMPH primarily caused firing rate reductions; excitations were limited to a subset of neurons.
These excited neurons showed peak activity during the fifth AMPH exposure and remained elevated during challenge.

Conclusions:

AMPH-induced adaptations in mPFC neuronal function are less pronounced than behavioral changes.
Observed mPFC adaptations are confined to neurons exhibiting excitation in response to AMPH.
These findings highlight specific neural substrates involved in AMPH sensitization.