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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Related Experiment Video

Updated: Jun 17, 2026

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro

Published on: June 16, 2022

NFATc1: functions in osteoclasts.

Qingxiao Zhao¹, Xi Wang, Yuehua Liu

¹College of Chemical Engineering, Northeast Dianli University, Changchun Road 169, Jilin, PR China. zhaoqingxiao@163.com

The International Journal of Biochemistry & Cell Biology

|December 29, 2009

Summary

Nuclear Factor of Activated T-cells cytoplasmic 1 (NFATc1) is crucial for bone remodeling. This review highlights NFATc1

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Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro

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Published on: March 18, 2019

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Last Updated: Jun 17, 2026

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro

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Published on: June 16, 2022

Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro

Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro

Published on: March 18, 2019

Area of Science:

Molecular Biology
Cell Biology
Immunology

Background:

NFATc1 is a key transcription factor.
It regulates T-cell differentiation, development, and bone biology.

Purpose of the Study:

To review the structure, function, and roles of NFATc1.
To highlight its significance in physiological and pathophysiological processes.

Main Methods:

Literature review of NFATc1 research.
Analysis of NFATc1's regulatory mechanisms.

Main Results:

NFATc1 is a master regulator of osteoclast differentiation.
It controls osteoclast fusion and activation.
NFATc1 up-regulates genes for bone resorption.

Conclusions:

NFATc1 is vital for osteoclastogenesis and bone homeostasis.
Understanding NFATc1 is critical for bone-related diseases.