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Updated: Jun 17, 2026

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
Published on: August 4, 2023
Circulating procoagulant microparticles in acute pulmonary embolism: a case-control study
Laurence Bal1, Stéphane Ederhy1, Emanuele Di Angelantonio1
1Cardiology Department, Saint-Antoine University and Medical School, France; Université Pierre et Marie Curie, Paris, France.
Abstract:
We investigated whether circulating procoagulant microparticles (CPMPs) contributed to hypercoagulability in 45 patients with acute pulmonary embolism (APE) and in 45 controls with and 45 controls without cardiovascular risk factors. Concentrations of CPMPs and platelet-derived microparticles (PMPs) were statistically significantly higher in patients with APE than in controls without cardiovascular risk factors. PMPs appeared to be the main source of procoagulant microparticle release in APE, but this correlation disappeared when APE patients were compared to controls with cardiovascular risk factors. CPMPs may have a role in venous thrombosis as mediators of cardiovascular risk factors.
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