Aporphine and bisaporphine alkaloids from Aristolochia lagesiana var. intermedia
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Published on: December 8, 2023
Marcia L R Ferreira1, Inara C de Pascoli, Isabele R Nascimento
1Instituto de Química, São Paulo State University, UNESP, C.P. 355, 14801-970 Araraquara, SP, Brazil.
Abstract:
Corydines, isocorydines, and analogous aporphine alkaloids were isolated from the leaves of Aristolochia lagesiana var. intermedia, together with three bisaporphine salts (lagesianines B-D). Their structures were determined by chemical derivatizations and spectroscopic analyses. Lagesianines B and C are the first examples of N-CH(2)-N' and C-2-O-C-1' linked dimeric aporphine alkaloids, respectively, while the monomeric units of lagesianine D, which has a carbon skeleton, are linked through C-7-C-5'via an ethane-1,2-diol group (C-7-CHOHCHOH-C-5').
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