Related Experiment Video
Updated: Jun 17, 2026

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
Published on: April 18, 2019
Synergistic effects between aminoethyl-chitosans and beta-lactams against methicillin-resistant Staphylococcus aureus
Dae-Sung Lee1, Young-Mog Kim, Myung-Suk Lee
1Department of Microbiology, Pukyong National University, Busan 608-737, Republic of Korea.
Abstract:
Two kinds of aminoethyl-chitosans (AEC), AEC90 and AEC50, which had degrees of deacetylation of 90% and 50%, respectively, were prepared and their synergistic effects in combination with beta-lactams including ampicillin, penicillin, and oxacillin against two standard methicillin-resistant Staphylococcus aureus (MRSA) strains and twelve clinical isolated MRSA strains were investigated. When AECs and beta-lactams were combined, synergistic effects were observed with fractional inhibitory concentration (FIC) indices of 0.252-0.508, and the MICs of beta-lactams in the presence of AECs were dramatically reduced.
Related Concept Videos
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Clinical Significance of Antibiotic Resistance
Mechanism of Antibiotic Resistance in MRSA
Inhibitors of Gram-positive Cell Wall Synthesis
Inhibitors of Bacterial Protein Synthesis
Staphylococcal Skin Infections
