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NMR Spectrometers: Resolution and Error Correction

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Methods of Ex Situ and In Situ Investigations of Structural Transformations: The Case of Crystallization of Metallic Glasses
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Published on: June 7, 2018

Crystal quality enhancement by magnetic fields.

Gen Sazaki1

  • 1Institute for Materials Research, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan. sazaki@lowtem.hokudai.ac.jp <sazaki@lowtem.hokudai.ac.jp>

Progress in Biophysics and Molecular Biology
|December 29, 2009
PubMed
Summary

Magnetic fields improve protein crystal quality by orienting crystals and reducing solution convection. This review covers magnetic field effects on protein crystallization, mechanisms, and future research directions.

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Last Updated: Jun 17, 2026

Methods of Ex Situ and In Situ Investigations of Structural Transformations: The Case of Crystallization of Metallic Glasses
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Area of Science:

  • Biophysics
  • Materials Science
  • Crystallography

Background:

  • Since the late 1990s, research has explored magnetic field applications in protein crystallization.
  • Protein crystal quality is crucial for structural determination and drug development.

Purpose of the Study:

  • To review the effects of magnetic fields on protein crystallization.
  • To elucidate the mechanisms behind magnetic field-induced enhancements.
  • To identify key areas for future research in this field.

Main Methods:

  • Review of existing scientific literature on magnetic field effects in protein crystallization.
  • Analysis of studies employing homogeneous and inhomogeneous magnetic fields.
  • Examination of experimental data on crystal quality, kinetics, and habit.

Main Results:

  • Homogeneous and gradient magnetic fields enhance protein crystal quality.
  • Magnetic orientation of protein molecules and suppression of buoyancy convection are key mechanisms.
  • Magnetic fields influence crystallization kinetics and alter crystal habit.

Conclusions:

  • Magnetic field application is a promising technique for improving protein crystallization.
  • Further research is needed to fully understand and optimize magnetic field parameters.
  • Future studies should focus on advanced magnetic field configurations and in-situ monitoring.