Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implantable Vagus Nerve Stimulator-Paired Neurorehabilitation for Upper Limb Function After Ischemic Stroke: Evidence From a Systematic Review and Meta-Analysis With Best Practice Recommendations: Corrigendum.

Neurosurgery·2026
Same author

Comparative Seizure Outcomes of Vagus Nerve Stimulation, Deep Brain Stimulation, and Their Combination in Lennox-Gastaut Syndrome.

Annals of neurology·2026
Same author

Thalamocortical seizure onset patterns in drug-resistant focal epilepsy.

Brain communications·2026
Same author

A stereotactic laser interstitial thermal therapy strategy to flank dense calcifications within epileptogenic lesions: illustrative case.

Journal of neurosurgery. Case lessons·2026
Same author

Kainic acid pig model of hippocampal epilepsy.

Scientific reports·2026
Same author

Development of an Educational Curriculum for the Surgical Implantation of DBS Systems.

Neuromodulation : journal of the International Neuromodulation Society·2026

Related Experiment Video

Updated: Jun 17, 2026

Operative Technique and Nuances for the Stereoelectroencephalographic (SEEG) Methodology Utilizing a Robotic Stereotactic Guidance System
04:50

Operative Technique and Nuances for the Stereoelectroencephalographic (SEEG) Methodology Utilizing a Robotic Stereotactic Guidance System

Published on: June 9, 2023

Semi-automatic stereotactic coordinate identification algorithm for routine localization of Deep Brain Stimulation

Adam O Hebb1, Kai J Miller

  • 1Department of Neurosurgery, University of Washington, Seattle, WA 98195, United States. aohebb@u.washington.edu

Journal of Neuroscience Methods
|December 29, 2009
PubMed
Summary

A new method accurately pinpoints Deep Brain Stimulation (DBS) implant locations using MRI and CT scans. This precise localization is crucial for validating targets and comparing treatment efficacy in movement disorders.

More Related Videos

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation
10:52

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation

Published on: October 2, 2015

Robotic-Guided Stereoelectroencephalography for Invasive Epilepsy Monitoring
11:28

Robotic-Guided Stereoelectroencephalography for Invasive Epilepsy Monitoring

Published on: June 13, 2025

Related Experiment Videos

Last Updated: Jun 17, 2026

Operative Technique and Nuances for the Stereoelectroencephalographic (SEEG) Methodology Utilizing a Robotic Stereotactic Guidance System
04:50

Operative Technique and Nuances for the Stereoelectroencephalographic (SEEG) Methodology Utilizing a Robotic Stereotactic Guidance System

Published on: June 9, 2023

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation
10:52

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation

Published on: October 2, 2015

Robotic-Guided Stereoelectroencephalography for Invasive Epilepsy Monitoring
11:28

Robotic-Guided Stereoelectroencephalography for Invasive Epilepsy Monitoring

Published on: June 13, 2025

Area of Science:

  • Neurosurgery
  • Medical Imaging
  • Neurology

Background:

  • Deep Brain Stimulation (DBS) is a standard treatment for movement disorders.
  • Emerging indications for DBS are expanding its clinical applications.
  • Accurate localization of DBS implants is vital for therapeutic targeting and efficacy assessment.

Purpose of the Study:

  • To present a novel protocol for defining stereotactic coordinates of metallic DBS implants.
  • To enable routine validation of therapeutic anatomical targets for DBS.
  • To improve the accuracy of DBS contact localization.

Main Methods:

  • Utilized volumetric MRI and CT scans in extended Hounsfield unit (EHU) mode.
  • Formatted MRI data to the Anterior Commissure-Posterior Commissure (AC-PC) coordinate system.
  • Implemented a semi-automatic detection algorithm using Normalized Mutual Information (NMI) co-registration for DBS contact localization.
  • Validated the algorithm against manual DBS contact identification.

Main Results:

  • Analyzed 50 MRI-CT image pairs from 39 patients with 336 DBS electrodes.
  • Achieved median and mean Euclidean distance errors of 0.20mm and 0.22mm, respectively, for automatic electrode localization.
  • Demonstrated high accuracy in localizing active DBS contacts within the sub-cortical region.

Conclusions:

  • The developed method provides accurate localization of DBS contacts.
  • This protocol can be routinely employed for validating therapeutic anatomical targets.
  • Accurate implant localization is essential for understanding clinical benefits and comparing DBS efficacy across subjects as indications expand.