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Danish patients with chronic pancreatitis have a four-fold higher mortality rate than the Danish population

Camilla Nøjgaard1, Flemming Bendtsen, Ulrik Becker

  • 1Department of Gastroenterology, Hvidovre Hospital, Copenhagen, Denmark. mille@dadlnet.dk

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
|December 29, 2009
PubMed

Insights

Patients with definite chronic pancreatitis (CP) face a 4-fold higher mortality rate than the general population. Non-employment and being underweight significantly impact survival in CP patients.

Area of Science:

  • Gastroenterology
  • Epidemiology
  • Clinical Medicine

Background:

  • Chronic pancreatitis (CP) is a significant health concern with potential impacts on patient survival.
  • Understanding the mortality risks associated with CP is crucial for patient management and prognosis.

Purpose of the Study:

  • To investigate the mortality rates of patients with chronic pancreatitis (CP) compared to the general Danish population.
  • To identify clinical factors influencing prognosis and causes of death in CP patients.

Main Methods:

  • Prospective study (Copenhagen Pancreatitis Study) of patients diagnosed with acute or chronic pancreatitis between 1977-1982.
  • Follow-up data collected in 2008 from Danish Registries for a subcohort of 290 probable or definite CP patients.

Main Results:

  • Definite CP patients exhibited a 4-fold higher mortality rate than the Danish population; probable CP patients had a 2-3 fold higher rate.
  • Non-employment and underweight status were significantly associated with increased mortality in definite CP patients.
  • Digestive diseases, malignancies, and cardiovascular diseases were the leading causes of death.

Conclusions:

  • Danish patients with definite CP have substantially higher mortality than the general population and those with probable CP.
  • Non-employment and underweight status are critical prognostic indicators for survival in chronic pancreatitis.
Abstract

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