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Cancer

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

Cancer-Critical Genes I: Proto-oncogenes

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Cancer-Critical Genes I: Proto-oncogenes

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Psychoneuroimmunology: Diabetes and Cancer

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...

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Related Experiment Video

Updated: Jun 17, 2026

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

Inflammation and oncogenesis: a vicious connection.

Sergei I Grivennikov¹, Michael Karin

¹Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

Current Opinion in Genetics & Development

|December 29, 2009

Summary

Inflammation is closely linked to cancer development, impacting all stages of tumor progression. Understanding these cancer-promoting inflammatory pathways is key for developing new prevention and therapy strategies.

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A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

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Published on: September 20, 2016

Area of Science:

Oncology
Immunology
Molecular Biology

Background:

Growing evidence links inflammation with cancer development.
Immune cells and inflammation are prevalent in solid tumors.
Inflammation affects multiple stages of tumorigenesis.

Purpose of the Study:

To review the general mechanisms connecting inflammation and cancer.
To discuss concepts of inflammation-driven tumorigenesis.
To highlight molecular and cellular pathways as therapeutic targets.

Main Methods:

Literature review of epidemiological and experimental data.
Synthesis of current understanding on inflammation and cancer.
Discussion of molecular and cellular mechanisms.

Main Results:

Inflammation is a significant factor in tumorigenesis.
Specific pathways linking inflammation and cancer are identified.
These pathways represent potential targets for intervention.

Conclusions:

The interplay between inflammation and cancer is complex and multifaceted.
Targeting cancer-promoting inflammation offers promising avenues for prevention and therapy.
Further research into these pathways is warranted.