Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Dual-Channel Strain Gauge Force Plate System with Hardware-Triggered Synchronization for Countermovement Jump Analysis.

Sensors (Basel, Switzerland)·2026

Same author

Preliminary evaluation of a DDA cationic liposome-based pulmonary mucosal immunization platform carrying a SARS-CoV-2 spike-derived branched peptide.

Frontiers in immunology·2026

Same author

A review of exosome isolation based on membrane protein recognition: Methods, performance, and challenges.

Analytica chimica acta·2026

Same author

Engineered Polylactic Acid (PLA) Microcapsules for Spatiotemporally Coupled Delivery and Synergistically Enhanced Dual Immunity.

Pharmaceutics·2026

Same author

Green preparation of graphene oxide-incorporated monoliths for pH-controlled protein enrichment and clinical biomarker detection.

Analytica chimica acta·2026

Same author

Memory consolidation deficits arise from CB1R-mediated structural-functional decoupling in inhibitory circuits.

Neurobiology of disease·2026

Search research articles

Related Experiment Video

Updated: Jun 17, 2026

Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

A comparative study on two phenylboronic acid based glucose-sensitive hydrogels.

Fenghua Xu¹, Guiyang Liu, Qiang Zhang

¹School of Pharmaceutical Sciences, Peking University, Beijing 100083, China.

Frontiers in Bioscience (Elite Edition)

|December 29, 2009

Summary

Two novel phenylboronic acid hydrogels show glucose sensitivity. These smart materials act as reversible valves, responding to physiological glucose levels for potential applications in fluid control.

More Related Videos

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Related Experiment Videos

Last Updated: Jun 17, 2026

Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Area of Science:

Materials Science
Polymer Chemistry
Biomedical Engineering

Background:

Developing glucose-sensitive materials is crucial for advanced diagnostics and therapeutics.
Phenylboronic acid (PBA) based hydrogels offer potential for specific glucose recognition.

Purpose of the Study:

To synthesize and characterize two PBA-based hydrogels for glucose-responsive applications.
To evaluate their swelling behavior and potential as "valves" for glucose solutions.

Main Methods:

Free-radical polymerization to synthesize hydrogels A.PBA-DMAPMA-EGDMA and A.PBA-PEG.
Swelling studies in buffer solutions with varying pH and glucose/fructose concentrations.
Analysis of hydrogel diameter changes to determine stimuli-responsiveness.

Main Results:

A.PBA-DMAPMA-EGDMA showed pH and glucose sensitivity, shrinking in basic conditions with increased glucose, forming a 1:2 PBA-glucose complex.
A.PBA-PEG exhibited pH, glucose, and fructose sensitivity, swelling in basic conditions, forming a 1:1 PBA-carbohydrate complex.
Both hydrogels demonstrated reversible responses within physiological glucose ranges and sufficient volume changes for valve applications.

Conclusions:

The synthesized PBA-based hydrogels exhibit tunable glucose sensitivity.
These hydrogels can function as reversible valves for controlling liquid flow based on glucose concentration.
The distinct complexation mechanisms (1:2 vs. 1:1) influence their specific responses to glucose and fructose.