Related Experiment Video

Updated: Jun 17, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
05:14

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

Dilated cardiomyopathy: etio-morphologic investigation

Brian Chiu1, Consolato Sergi

  • 1Department of Laboratory Medicine and Pathology, University of Alberta Hospital, University of Alberta, Edmonton, Alberta, Canada. brian.chiu@capitalhealth.ca

Frontiers in Bioscience (Scholar Edition)
|December 29, 2009
PubMed

Insights

Dilated cardiomyopathy, a common heart condition, involves heart chamber dilation and impaired pumping. This study reviewed the causes and features of explanted hearts from transplant recipients to better understand this complex disease.

Area of Science:

  • Cardiovascular Science
  • Developmental Biology
  • Pathology

Background:

  • The heart forms early in vertebrate embryogenesis and is vital for life.
  • Compromised heart function leads to chamber dilation and altered circulation.
  • Dilated cardiomyopathy (DCM) presents variably, from asymptomatic to heart failure.

Purpose of the Study:

  • To review the etiologic and morphologic features of explanted adult hearts with DCM.
  • To analyze hearts from patients undergoing orthotopic heart transplantation.

Main Methods:

  • Retrospective review of 86 explanted adult hearts.
  • Analysis of hearts from patients diagnosed with dilated cardiomyopathy.
  • Study period: 1997-2008.

Main Results:

  • Dilated cardiomyopathy exhibits nonspecific pathologic features, complicating etiological identification.
  • Etiologic and morphologic characteristics were examined in explanted hearts.

Conclusions:

  • Understanding the etiologic and morphologic features of DCM is crucial.
  • Further research is needed to elucidate the diverse causes of dilated cardiomyopathy.

More Related Videos

Echocardiographic and Histological Examination of Cardiac Morphology in the Mouse10:22

Echocardiographic and Histological Examination of Cardiac Morphology in the Mouse

Published on: October 26, 2017

Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease12:15

Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease

Published on: February 8, 2022

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...