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Related Concept Videos

Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors
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Cancer stem cell and niche.

Daotai Nie1

  • 1Department of Medical Microbiology, Southern Illinois University School of Medicine and SimmonsCooper Cancer Institute, Springfield, IL 62794-9626, USA. dnie@siumed.edu

Frontiers in Bioscience (Scholar Edition)
|December 29, 2009
PubMed
Summary

The cancer stem cell model explains therapy resistance by highlighting how self-renewing cancer stem cells (CSCs) within a niche drive tumor growth. Understanding CSCs and their niche is crucial for developing effective cancer treatments.

Area of Science:

  • Oncology
  • Stem Cell Biology
  • Cancer Research

Background:

  • Conventional cancer therapies often fail due to inherent resistance mechanisms.
  • The cancer stem cell (CSC) model offers a new paradigm for understanding tumor growth and heterogeneity.
  • Tumor tissues are sustained by self-renewing stem cells residing in specialized microenvironments called niches.

Purpose of the Study:

  • To review the cancer stem cell model of tumor development.
  • To elucidate the role of stem cells in tumor progression.
  • To examine the components and regulatory factors of the CSC niche and their clinical implications.

Main Methods:

  • Literature review of cancer stem cell research.
  • Analysis of models describing cancer development.

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  • Synthesis of information on niche components and regulatory factors.

    • Main Results:

    • Cancer stem cells (CSCs) are key drivers of tumor initiation and progression.
    • The tumor microenvironment (niche) significantly influences CSC behavior and fate.
    • Specific cellular and extracellular components constitute the CSC niche.

    Conclusions:

    • The cancer stem cell model provides a framework for understanding therapeutic challenges.
    • Targeting CSCs and their niche represents a promising strategy for novel cancer therapies.
    • Further research into CSC niche interactions is essential for clinical advancements.