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Related Experiment Video

Updated: Jun 17, 2026

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

Published on: October 27, 2014

Bevacizumab (Avastin).

¹Department of Radiology, University of Michigan Health System, Ann Arbor, Michigan 48109-5030, USA. mukherji@umich.edu

AJNR. American Journal of Neuroradiology

|December 29, 2009

Summary

This summary is machine-generated.

Bevacizumab, a monoclonal antibody, was the first FDA-approved therapy targeting angiogenesis. This review covers its mechanism and clinical applications as an antiangiogenic agent.

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Published on: September 18, 2019

Area of Science:

Oncology
Immunology
Pharmacology

Background:

Bevacizumab is a pioneering FDA-approved therapy.
It functions as a humanized monoclonal antibody.
Its primary target is angiogenesis, a key process in tumor growth.

Purpose of the Study:

To review the mechanism of action of Bevacizumab.
To discuss the clinical role of Bevacizumab.
To provide an overview of this antiangiogenic agent.

Main Methods:

Literature review of Bevacizumab.
Analysis of its pharmacological properties.
Synthesis of clinical data.

Main Results:

Bevacizumab inhibits vascular endothelial growth factor (VEGF).
VEGF inhibition disrupts tumor angiogenesis.
This leads to reduced tumor growth and metastasis.

Conclusions:

Bevacizumab is a significant antiangiogenic therapy.
Its mechanism involves blocking VEGF signaling.
It plays a crucial role in various cancer treatments.