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Cerebral microbleeds in predialysis patients with chronic kidney disease

Hideaki Shima1, Eiji Ishimura, Toshihide Naganuma

  • 1Department of Endocrinology, Metabolism and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|December 29, 2009
PubMed
Abstract

Insights

Chronic kidney disease (CKD) is linked to cerebral microbleeds (CMBs), detected by T2*-weighted MRI. Poor kidney function, independent of hypertension, increases CMB risk, potentially indicating future cerebrovascular events.

Area of Science:

  • Neurology
  • Nephrology
  • Radiology

Background:

  • Cerebral microbleeds (CMBs) are associated with cerebrovascular events and small vessel disease.
  • Chronic kidney disease (CKD) is an independent cardiovascular disease risk factor.
  • The link between CKD and CMBs requires further investigation.

Purpose of the Study:

  • To investigate the relationship between chronic kidney disease (CKD) and cerebral microbleeds (CMBs).
  • To determine if decreased renal function is an independent risk factor for CMBs.

Main Methods:

  • A cross-sectional study involving 162 CKD patients (stages 1-5, excluding 5(D)) and 24 healthy controls.
  • Brain T2*-weighted MRI was performed using a 1.5-T system.
  • Patient data included age, gender, blood pressure, diabetes mellitus, dyslipidemia, and estimated glomerular filtration rate.

Main Results:

  • CMBs were detected in 25.6% of CKD patients, but not in controls.
  • CMB prevalence increased with CKD stage and was higher in males, those with higher blood pressure, and older age.
  • Lower estimated glomerular filtration rate was significantly associated with CMB prevalence, independent of other factors.

Conclusions:

  • Decreased renal function is a significant risk factor for CMBs, independent of hypertension.
  • Poor kidney function may be linked to an increased risk of future cerebrovascular events.

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