[A case of advanced gastric cancer treated with S-1 and S-1/paclitaxel showing complete response twice]

The patient was a 76-year-old man with advanced gastric cancer located in cardia, and was diagnosed to have an invasion to diaphragma and multiple lymph node metastases. We treated successfully with 12-course of S-1 chemotherapy. But second primary gastric cancer was detected in antrum 26 months after primary therapy. We treated with S-1/paclitaxel ( PTX) combined chemotherapy. S-1 (80 mg/m2) was orally administered for 2 weeks followed by a week interval and PTX (50 mg/m2) was also administered days 1 and 8. One course of chemotherapy was 21 days. GIF and abdominal CT revealed complete response (CR) after 3 courses of chemotherapy. We are now going on 6 courses of chemotherapy and the patient did not experience any grade 3 adverse effects.