[Neurophysiological and neurohistological analysis of striatal hyperkineses in the treatment with stereotaxic method]

A stereotaxic method has been used for the electrostimulation with the following electrolytic destruction of brain structures in 86 patients (54 male and 32 female, aged from 6 to 52 years). The sample included 16 patients with torsion dystonia, 36 - with athetosis, 25 - with choreoathetosis and 9 with Huntington's chorea. The decrease of intensity of hyperkineses has been achieved in 81% of patients, no effect has been found in 19%, 1 patient died. Striatum, thalamus, motor and premotor neocortex, Cajal nucleus, dentate nucleus of cerebellum, subthalamic area (fields H7 and H2 of Forel) were used as stereotaxic targets. Data on the neurophysiological basis of changes of the pathological impulsion underlying hyperkineses are obtained. This finding has been confirmed by some neurohistological signs.