Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implications of race-neutral equations on interpretation of lung function in Australia.

Internal medicine journal·2026
Same author

Childhood Pulmonary Virus Infection and Future Bronchiectasis.

Archivos de bronconeumologia·2025
Same author

Pirfenidone Mitigates Transforming Growth Factor-β-induced Inflammation after Viral Infection.

American journal of respiratory cell and molecular biology·2025
Same author

Impaired diffusing capacity and COPD incidence in adults with symptoms and normal spirometry.

Respiratory medicine·2024
Same author

Current physiotherapy practice for adults with bronchiectasis: Data from the Australian bronchiectasis registry.

Respiratory medicine·2024
Same author

Neutrophil Extracellular Traps and Respiratory Disease.

Journal of clinical medicine·2024
Same journal

Real-Life Effectiveness of Aclidinium/Formoterol on COPD Control: The REDACT Observational Study.

International journal of chronic obstructive pulmonary disease·2026
Same journal

Effective-Component Compatibility of Bufei Yishen Formula Alleviates Alveolar Epithelial Barrier Damage in COPD Through Inhibition of p38 MAPK Phosphorylation.

International journal of chronic obstructive pulmonary disease·2026
Same journal

Cardiopulmonary Exercise Testing and Quantitative Chest CT in COPD: The Stronger Association of Emphysema Over Airway Thickness with Functional Impairment.

International journal of chronic obstructive pulmonary disease·2026
Same journal

A Nomogram for Predicting Successful Weaning from Invasive Mechanical Ventilation Withdrawal in Patients with Chronic Obstructive Pulmonary Disease Complicated by Respiratory Failure.

International journal of chronic obstructive pulmonary disease·2026
Same journal

Diagnostic Value of miR-192-5p in the Progression of Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Heart Disease.

International journal of chronic obstructive pulmonary disease·2026
Same journal

Association Between Chronic Obstructive Pulmonary Disease and Survival in Patients with Lung Cancer: A Nationwide Cohort Study.

International journal of chronic obstructive pulmonary disease·2026
See all related articles

Related Experiment Video

Updated: Jun 17, 2026

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

The pathophysiology of bronchiectasis.

Paul T King1

  • 1Department of Medicine, Monash University, Monash Medical Centre, Melbourne, Victoria, Australia. paul.king@med.monash.edu.au

International Journal of Chronic Obstructive Pulmonary Disease
|December 29, 2009
PubMed
Summary
This summary is machine-generated.

Bronchiectasis involves permanent widening of bronchi due to chronic infection and inflammation, leading to airflow obstruction. This review details the pathophysiology of non-cystic fibrosis bronchiectasis and its progressive lung function decline.

Keywords:
bronchiectasisinflammationobstructive lung diseasepathologypathophysiology

More Related Videos

The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections
06:57

The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections

Published on: May 8, 2017

Related Experiment Videos

Last Updated: Jun 17, 2026

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections
06:57

The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections

Published on: May 8, 2017

Area of Science:

  • Pulmonology
  • Pathophysiology
  • Medical Imaging

Background:

  • Bronchiectasis is defined as permanent bronchial widening, often linked to chronic airway infection and inflammation.
  • Diagnosis typically involves computed tomography (CT) scanning to visualize enlarged bronchi.
  • It is associated with mild to moderate airflow obstruction.

Purpose of the Study:

  • To review the pathophysiology of non-cystic fibrosis bronchiectasis.
  • To discuss the role of small airway obstruction due to inflammatory infiltrates.
  • To explore etiologic risk factors and pathogen involvement.

Main Methods:

  • Review of existing studies on bronchiectasis pathophysiology.
  • Analysis of small airway obstruction mechanisms.
  • Examination of risk factors and microbial flora changes.

Main Results:

  • Small airway obstruction in bronchiectasis results from inflammatory infiltrates thickening bronchial walls.
  • Patients with bronchiectasis exhibit a progressive decline in lung function.
  • Despite purulent sputum, pathogenic microorganisms are often not identified, and bacterial flora changes with disease progression.

Conclusions:

  • Non-cystic fibrosis bronchiectasis involves complex pathophysiology with significant small airway involvement.
  • Progressive lung function decline is a key feature.
  • Etiology is multifactorial, with challenges in identifying specific risk factors and pathogens.