Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Autoimmune Disorders

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...

Gastritis-II: Pathophysiology

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...

Inflammatory Bowel Disease III: Crohn's Disease

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cross-sectional comparison of cardiometabolic markers in transgender men receiving gender-affirming hormone therapy.

Endocrine·2026

Same author

Associations between ambient air pollution and mortality during a 7-year ecological time-series study.

Scientific reports·2026

Same author

Does persistent hyperprolactinemia contribute to bone loss independently of estrogen deficiency in postmenopausal women?

Pituitary·2026

Same author

Socioeconomic status in Behçet's syndrome.

Clinical and experimental rheumatology·2026

Same author

Booster mRNA Vaccination Prevents Breakthrough Severe COVID-19 Infections.

Journal of medical virology·2026

Same author

A log-adjusted t-statistic for large clinical laboratory datasets: a simulation study and real-world application.

Scandinavian journal of clinical and laboratory investigation·2026

Search research articles

Related Experiment Video

Updated: Jun 17, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Autoantibody frequency in celiac disease.

Erkan Caglar¹, Serdal Ugurlu, Aliye Ozenoglu

¹Division of Gastroenterology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University - Istanbul, Turkey.

Clinics (Sao Paulo, Brazil)

|December 29, 2009

Summary

Celiac disease patients did not show increased autoimmune antibodies common in other conditions. However, autoimmune hypothyroid patients had significantly higher levels of anti-thyroid antibodies (anti-TPO and anti-TG).

Keywords:

Antinuclear antibodies Autoimmune antibodies Autoimmune diseases Autoimmune hypothyroid patients Celiac disease

More Related Videos

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases

Published on: May 29, 2020

Related Experiment Videos

Last Updated: Jun 17, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases

Published on: May 29, 2020

Area of Science:

Immunology
Endocrinology
Gastroenterology

Background:

Celiac disease is an autoimmune disorder with potential links to other autoimmune conditions.
Previous research suggests an increased prevalence of autoimmune diseases in celiac patients.
Investigating specific autoantibodies can clarify these associations.

Purpose of the Study:

To compare autoantibody profiles in celiac disease patients versus healthy controls and autoimmune hypothyroid patients.
To determine if celiac disease is associated with a higher frequency of antibodies targeting other organs.
To assess specific autoantibodies including anti-GAD, ICA, anti-TPO, anti-TG, ANA, anti-ds DNA, anti-SSA, anti-SSB, anti-Sm, ASMA, and AMA-LKM.

Main Methods:

Retrospective analysis of 31 celiac disease patients, 34 autoimmune hypothyroidism patients, and 29 healthy controls.
Enzyme-Linked Immunosorbent Assay (ELISA) for anti-SSA, anti-SSB, anti-Sm, anti-ds DNA, anti-GAD, anti-TPO, and anti-TG.
Immunofluorescence for AMA-LKM, ASMA, ANA, and ICA; statistical analysis using SPSS and chi-squared test.

Main Results:

No significant difference in the frequency of anti-SSA, anti-SSB, anti-GAD, anti-Sm, anti-ds DNA, AMA-LKM, ASMA, ANA, and ICA between the groups.
Autoimmune hypothyroid patients exhibited significantly higher levels of anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) antibodies compared to celiac disease and control groups (<0.001).

Conclusions:

The study found no increased frequency of autoantibodies specific to other autoimmune diseases in celiac disease patients.
Elevated anti-TPO and anti-TG antibodies are characteristic of autoimmune hypothyroidism, as expected.
This research clarifies that celiac disease, in this cohort, is not associated with a broader spectrum of other specific autoimmune antibodies.