PPARs in Irradiation-Induced Gastrointestinal Toxicity
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Updated: Jun 17, 2026

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
Published on: July 27, 2022
Christine Linard1, Maâmar Souidi
1Institute for Radioprotection and Nuclear Safety, B.P. no.17, 92262 Fontenay aux Roses Cedex, France.
Abstract:
The use of radiation therapy to treat cancer inevitably involves exposure of normal tissues. Although the benefits of this treatment are well established, many patients experience distressing complications due to injury to normal tissue. These side effects are related to inflammatory processes, and they decrease therapeutic benefit by increasing the overall treatment time. Emerging evidence indicates that PPARs and their ligands are important in the modulation of immune and inflammatory reactions. This paper discusses the effects of abdominal irradiation on PPARs, their role and functions in irradiation toxicity, and the possibility of using their ligands for radioprotection.
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