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Updated: Jun 17, 2026

Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse

Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse

Published on: October 24, 2018

Quantifying recirculation in extracorporeal membrane oxygenation: a new technique validated.

Steven J Lindstrom¹, Mark T Mennen, Franklin L Rosenfeldt

¹Department of Epidemiology and Preventive Medicine, Monash University, Victoria, Australia. s.lindstrom@alfred.org.au

The International Journal of Artificial Organs

|December 29, 2009

Summary

Measuring recirculation during extracorporeal membrane oxygenation (ECMO) is crucial. Using blood oxygen content is more accurate than saturation alone, and a new step-change technique effectively quantifies recirculation in vivo.

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Published on: July 14, 2023

Area of Science:

Cardiovascular Research
Biomedical Engineering
Critical Care Medicine

Background:

Efficacy of veno-venous extracorporeal membrane oxygenation (ECMO) is limited by recirculation.
Accurate quantification of recirculation is challenging with current methods.
Existing techniques using standard equipment are unsatisfactory for measuring recirculation.

Purpose of the Study:

Compare accuracy of recirculation measurements using blood oxygen content versus saturation.
Validate a novel step-change technique for in vivo recirculation quantification.
Improve accuracy in assessing ECMO efficiency and patient outcomes.

Main Methods:

Ex vivo circuit in greyhound dogs to create known recirculation levels.
Comparison of blood oxygen content and saturation measurements for recirculation.
In vivo validation of a step-change technique using oxygen content during ECMO.

Main Results:

Oxygen content measurements showed superior correlation (r(2)=0.87) and less bias compared to oxygen saturation (r(2)=0.64).
The novel step-change technique for in vivo recirculation measurement demonstrated excellent correlation (r(2)=0.89).
Step-change technique in vivo overestimation was 18.6% (95% CI: 3.9-33.2%).

Conclusions:

Blood oxygen content is a superior parameter for measuring recirculation compared to oxygen saturation alone.
The novel step-change technique provides accurate in vivo measurement of recirculation in animal models.
This technique offers a promising tool for optimizing ECMO therapy and patient management.