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Published on: April 13, 2015

Diastolic dysfunction in diabetic patients assessed with Doppler echocardiography: relationship with coronary

Javier Escaned1, Humberto Colmenárez, María Cruz Ferrer

  • 1Instituto Cardiovascular, Hospital Clínico San Carlos, 28040 Madrid, España. escaned@secardiologia.es

Revista Espanola De Cardiologia
|December 30, 2009
PubMed

Insights

Diabetic heart disease shows impaired diastolic function linked to microcirculation changes. This study found a relationship between left ventricular diastolic function and coronary microvascular resistance in diabetic patients.

Area of Science:

  • Cardiology
  • Diabetology
  • Medical Imaging

Background:

  • Diabetes mellitus (DM) is linked to impaired left ventricular diastolic function (LVDF) and coronary circulation abnormalities.
  • Understanding the interplay between these conditions is crucial for managing diabetic heart disease.

Purpose of the Study:

  • To investigate the relationship between LVDF and coronary macro- and microcirculation in patients with DM.
  • To assess how atherosclerosis severity relates to diastolic dysfunction.

Main Methods:

  • Intravascular ultrasound (IVUS) quantified atherosclerosis in the LAD of 13 DM patients.
  • Coronary flow velocity reserve (CFVR), IHDVPS, and zero-flow pressure were measured.
  • LVDF indices (E/A, E/e') were correlated with intracoronary measurements.

Main Results:

  • The E/e' ratio showed a direct relationship with coronary resistance (r=0.62, P=.02) and an inverse relationship with IHDVPS (r=-0.64, P=.02).
  • No significant correlation was found between LVDF indices and CFVR or zero-flow pressure.
  • Atheroma volume in the LAD did not correlate with LVDF indices.

Conclusions:

  • LVDF impairment, specifically the E/e' ratio, is related to structural changes in the coronary microcirculation in diabetic patients with coronary atherosclerosis.
Abstract

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