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Emerging multiple sclerosis oral therapies.

Kottil W Rammohan1, Jennifer Shoemaker

  • 1The MS Center, Columbus, OH 43221, USA. Kottil.Rammohan@osumc.edu

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|December 30, 2009
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Summary
This summary is machine-generated.

New oral therapies for multiple sclerosis (MS) show promise in clinical trials, potentially improving patient treatment adherence. These emerging oral compounds aim to offer relief for this chronic CNS disorder.

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Area of Science:

  • Neuroscience
  • Immunology
  • Pharmacology

Background:

  • Multiple sclerosis (MS) is a chronic CNS demyelinating disorder.
  • Current treatments for MS require injections, offering modest symptom relief.
  • Patient compliance and endorsement may improve with alternative administration routes.

Purpose of the Study:

  • To evaluate emerging orally available therapies for multiple sclerosis.
  • To compare the efficacy and safety profiles of novel oral MS treatments.
  • To assess the potential benefits of oral compounds against their adverse effects.

Main Methods:

  • Review of phase II and phase III clinical trials for oral MS therapies.
  • Analysis of efficacy data, including relapse rates and lesion activity.
  • Assessment of safety and tolerability data for the evaluated compounds.

Main Results:

  • Fingolimod (immunosuppressant) significantly reduced annual relapse rates.
  • Laquinimod (immunomodulator) decreased active lesions in phase II trials.
  • Cladribine (immunomodulator) reduced relapse rates and gadolinium-positive lesions in phase III trials.
  • Oral fumarate demonstrated immunomodulatory and antioxidant properties, lowering lesion counts.
  • Teriflunomide (immunomodulator) reduced MRI lesion activity and relapse rates.

Conclusions:

  • Several orally available therapies show significant efficacy in managing multiple sclerosis.
  • Oral administration of MS medications may enhance patient compliance.
  • Further evaluation of benefits versus risks is crucial for these novel oral treatments.