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Updated: May 12, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

New roles for Notch in tuberous sclerosis

Warren S Pear1

  • 1Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104-6160, USA. wpear@mail.med.upenn.edu

The Journal of Clinical Investigation
|December 30, 2009
PubMed
Summary

Tuberous sclerosis complex (TSC) involves benign tumors caused by TSC1/TSC2 gene mutations. New research links TSC gene inactivation to Notch signaling activation, suggesting Notch inhibitors may treat TSC tumors.

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