Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drying Shrinkage01:21

Drying Shrinkage

When hardened concrete is exposed to air with a relative humidity of less than 100 percent, it begins to lose the free water within its capillaries. As this water evaporates, the water initially adsorbed onto the calcium silicate hydrates migrates towards these now empty spaces and eventually evaporates as well. Over time, as more water leaves, the volume of the concrete decreases, a phenomenon known as drying shrinkage.
A portion of this drying shrinkage can be reversed; if the concrete is...
Washing, Drying, and Ignition of Precipitates00:52

Washing, Drying, and Ignition of Precipitates

After filtration, the precipitate is washed to remove coprecipitated impurities and any remaining mother liquor. Colloidal precipitates, such as silver chloride, are washed with an electrolyte (such as dilute nitric acid) to prevent the peptization of the precipitate. In the case of slightly soluble precipitates, the wash solution contains a common ion to reduce solubility. Lead sulfate, which is slightly soluble in water, is washed with dilute sulfuric acid. Similarly, wash solutions may be...
Special Staining Techniques01:13

Special Staining Techniques

Specialized staining techniques play a vital role in microbiology by enabling the visualization of specific bacterial structures that remain undetectable with standard microscopy methods. These techniques not only enhance the structural visualization of bacterial cells but also provide critical insights into their pathogenicity and classification. Additionally, they support diagnostic and research endeavors in microbiology by identifying key bacterial features.Capsule Staining for Virulence...
Dry Friction01:30

Dry Friction

Dry friction occurs between two solid surfaces in contact as they attempt to move relative to one another. In daily life, dry friction is encountered in various forms, such as when walking on the ground, sliding an object across a table, or rubbing hands together. Despite its ubiquity, the underlying mechanisms behind dry friction are not readily visible.
To illustrate this concept, imagine a wooden crate resting on a rough, non-uniform horizontal surface. When an external force is applied to...
Simple Staining Technique01:24

Simple Staining Technique

OverviewStaining techniques in microscopy enhance the visualization of microorganisms by increasing contrast and allowing the differentiation of cellular structures. Simple staining is one of the fundamental methods used to observe the basic morphological characteristics of microorganisms, including their size, shape, and arrangement. This method relies on the application of a single dye to stain the entire cell, producing a clear contrast between the cell and the background.FixationFixation is...
Differential Staining Technique01:26

Differential Staining Technique

Differential staining is an essential microbiological technique that exploits variations in cell wall structures to classify and identify microorganisms. It facilitates the distinction of bacteria, aiding in diagnostic and research applications. Two of the most widely used differential staining methods are Gram staining and acid-fast staining, both of which rely on the chemical and structural differences in bacterial cell walls.Gram Staining TechniqueGram staining differentiates bacteria by...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Organ-Specific Phytochemical Profiles, Wound-Healing and Hemostatic Activities of <i>Symphytum officinale</i> Aerial Parts and Roots with Differential Pyrrolizidine Alkaloid Content.

Molecules (Basel, Switzerland)·2026
Same author

A comparative evaluation of two clinical decision support systems for safer prescribing in older adults: an exploratory single-patient case study.

Frontiers in pharmacology·2026
Same author

Formulation and evaluation of semi-solid extrusion (SSE) 3D-printed drug preparations using poloxamers and polyethylene oxide as co-printed carrier polymers.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2026
Same author

Scoping review to identify data needs and environmental hotspots for future LCA Studies: Insights into pharmaceutical excipients and processes.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2026
Same author

Sustainable Extraction of the Tetrahydropalmatine Alkaloid from <i>Stephania rotunda</i> Lour. Tubers Using Eco-Friendly Solvent Systems.

ACS omega·2025
Same author

<i>Verbena officinalis</i> L. Herb Extract, Its Amino Acid Preparations and 3D-Printed Dosage Forms: Phytochemical, Technological and Pharmacological Research.

Plants (Basel, Switzerland)·2025
Same journal

Enhanced Stability and Transdermal Delivery of Semaglutide Using an L-Arginine Based Dissolving Microneedle System.

AAPS PharmSciTech·2026
Same journal

The Preparation and Physicochemical Characterization of a Triple Synergistic Nanoplatform Designed for Targeted Subcutaneous Delivery of Sitagliptin with Potential for β-Cell Preservation.

AAPS PharmSciTech·2026
Same journal

Repurposing Non-oncologic Drugs via Targeted Nanocarriers for Cancer Therapy: Mechanisms, Synergistic Combinations, and Clinical Translation.

AAPS PharmSciTech·2026
Same journal

Targeting Permeability Barriers By Strategic Selection of Thiol Containing Coformer for Novel Cocrystals of Metformin.

AAPS PharmSciTech·2026
Same journal

Plume Geometry Matters: Investigating the Contribution of Mass-Based Plume Geometry to Aerosol Delivery Efficiency in pMDIs.

AAPS PharmSciTech·2026
Same journal

Eigenrate-Based Thermodynamic Decomposition of Competing Release Mechanisms in Polymeric Nano- and Microspheres: The MMIR-S Framework with Arrhenius Dual-Population Burst Kinetics and Log-Normal Polydispersity Averaging.

AAPS PharmSciTech·2026
See all related articles

Related Experiment Video

Updated: Jun 17, 2026

Methods for the Self-integration of Megamolecular Biopolymers on the Drying Air-LC Interface
07:06

Methods for the Self-integration of Megamolecular Biopolymers on the Drying Air-LC Interface

Published on: April 7, 2017

Colorful drying.

Satu Lakio1, Jyrki Heinämäki, Jouko Yliruusi

  • 1Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland. satu.lakio@helsinki.fi

AAPS Pharmscitech
|December 30, 2009
PubMed
Summary
This summary is machine-generated.

Microencapsulated thermochromic pigments serve as effective heat indicators during pharmaceutical fluid bed drying. These color-changing indicators monitor heat flow in granules and pellets, aiding process understanding and scale-up.

More Related Videos

Fabric Moisture Uniform Control to Study the Influence of Air Impingement Parameters on Fabric Drying Characteristics
06:28

Fabric Moisture Uniform Control to Study the Influence of Air Impingement Parameters on Fabric Drying Characteristics

Published on: August 19, 2019

Preparation of Prokaryotic and Eukaryotic Organisms Using Chemical Drying for Morphological Analysis in Scanning Electron Microscopy (SEM)
09:58

Preparation of Prokaryotic and Eukaryotic Organisms Using Chemical Drying for Morphological Analysis in Scanning Electron Microscopy (SEM)

Published on: January 7, 2019

Related Experiment Videos

Last Updated: Jun 17, 2026

Methods for the Self-integration of Megamolecular Biopolymers on the Drying Air-LC Interface
07:06

Methods for the Self-integration of Megamolecular Biopolymers on the Drying Air-LC Interface

Published on: April 7, 2017

Fabric Moisture Uniform Control to Study the Influence of Air Impingement Parameters on Fabric Drying Characteristics
06:28

Fabric Moisture Uniform Control to Study the Influence of Air Impingement Parameters on Fabric Drying Characteristics

Published on: August 19, 2019

Preparation of Prokaryotic and Eukaryotic Organisms Using Chemical Drying for Morphological Analysis in Scanning Electron Microscopy (SEM)
09:58

Preparation of Prokaryotic and Eukaryotic Organisms Using Chemical Drying for Morphological Analysis in Scanning Electron Microscopy (SEM)

Published on: January 7, 2019

Area of Science:

  • Pharmaceutical Engineering
  • Materials Science
  • Process Analytical Technology

Background:

  • Drying is a critical unit operation in pharmaceutical manufacturing.
  • Understanding process conditions during drying is essential for product quality.
  • Heat-sensitive Active Pharmaceutical Ingredients (APIs) require careful temperature monitoring.

Purpose of the Study:

  • To evaluate microencapsulated thermochromic pigments as real-time heat indicators in fluid bed drying.
  • To assess the suitability of these pigments for monitoring heat flow in pharmaceutical powders.
  • To investigate the application of colorimetric measurements for process control.

Main Methods:

  • Manual granulation of thermochromic pigments with alpha-lactose monohydrate into three particle-size groups.
  • Coating pellets with the indicator powders.
  • Fluidization of granules and pellets in a fluid bed dryer.
  • Measurement of CIELAB color values using a tristimulus colorimeter.

Main Results:

  • Both prepared granules and pellets demonstrated utility as heat indicators in fluid bed drying.
  • The thermochromic pigments effectively indicated heat flow and temperature changes.
  • Colorimetric analysis provided real-time insights into the drying process.

Conclusions:

  • Microencapsulated thermochromic pigments are viable heat indicators for pharmaceutical fluid bed drying.
  • These indicators offer a novel method for real-time process monitoring and understanding.
  • Potential applications include quality control and process optimization, particularly during scale-up studies.