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Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...

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Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy
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Published on: May 16, 2022

Multifunctional imaging nanoprobes.

Peter A Jarzyna1, Anita Gianella, Torjus Skajaa

  • 1Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, New York, NY, USA.

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
|December 30, 2009
PubMed
Summary
This summary is machine-generated.

This review covers multifunctional imaging nanoprobes for tracking pathological processes and drug delivery. These advanced nanomaterials offer multimodal imaging and therapeutic potential, enhancing in vivo nanoparticle understanding.

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Area of Science:

  • Nanotechnology
  • Biomedical Imaging
  • Materials Science

Background:

  • Multifunctional imaging nanoprobes are crucial for studying diseases and drug delivery systems.
  • These probes can also be utilized for therapeutic purposes, such as thermal ablation, leveraging their physical properties.

Purpose of the Study:

  • To review four classes of nanoparticulate imaging probes.
  • To highlight the combination of biomaterials for creating multifunctional probes.
  • To demonstrate how multimodality imaging enhances understanding of nanoparticle behavior and efficacy.

Main Methods:

  • Categorization of probes into four classes based on functionality (multimodal tracking, drug delivery with bimodal imaging, nucleic acid delivery and imaging, thermal ablation capabilities).
  • Discussion of various (bio)materials (polymers, inorganic nanocrystals, fluorophores, proteins/peptides, lipids) used in probe fabrication.
  • Emphasis on multimodality imaging techniques for in vivo analysis.

Main Results:

  • Detailed presentation of four distinct classes of multifunctional imaging nanoprobes.
  • Examples showcasing the tailored design of probes using diverse nanomaterials.
  • Evidence of improved understanding of nanoparticle behavior and therapeutic efficacy through multimodality imaging.

Conclusions:

  • Multifunctional imaging nanoprobes are versatile tools for biomedical research and therapy.
  • The strategic combination of materials enables the development of advanced nanoprobe classes.
  • Multimodality imaging is essential for comprehensive in vivo evaluation of nanomedicines.