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Related Experiment Videos

Triptan use as a function of cardiovascular risk. A population-based study.

Marcelo E Bigal¹, Wendy Golden, Dawn Buse

¹Merck Research Laboratories, Whitehouse Station, NJ, USA.

|December 31, 2009

Summary

This summary is machine-generated.

Triptan use for migraine is lower in patients with cardiovascular risks or disease, but increases with disability, suggesting a balance between perceived risks and benefits.

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Area of Science:

Neurology
Cardiology
Public Health

Background:

Migraine is a common neurological disorder.
Triptans are a common class of acute migraine treatments.
Cardiovascular (CV) disease and risk factors may influence treatment choices.

Purpose of the Study:

To estimate the proportion of individuals with migraine using triptan therapy.
To analyze triptan use based on cardiovascular profile and migraine disease severity.

Main Methods:

Utilized data from the American Migraine Prevalence and Prevention study.
Identified a US adult population sample with migraine.
Assessed triptan use in relation to cardiovascular disease (CVD), CV risk factors, and migraine disability.

Main Results:

Triptan use was lower in individuals with diabetes, hypertension, or who smoked compared to those without CV risk factors.
Individuals with established CVD (myocardial infarct, stroke, heart surgery) were less likely to use triptans.
Triptan use increased with higher migraine-related disability, irrespective of CV risk status.

Conclusions:

Lower triptan use in patients with CV risk suggests potential patient or physician concerns about safety.
Increasing triptan use with disability in patients with CVD indicates a risk-benefit assessment by patients and providers.
Further research is needed on the safety of triptans in patients with CV risk.