Primary cutaneous CD30+ large-cell lymphoma presenting as a scrotal plaque

Area of Science:

• Dermatology
• Oncology
• Pathology

Background:

• Primary cutaneous CD30+ large-cell lymphoma (CD30+ LCL) is an uncommon non-Hodgkin lymphoma.
• It typically affects the skin, often presenting on the extremities or trunk.

Observation:

• A patient presented with a year-long history of a growing scrotal plaque.
• Skin biopsy confirmed the presence of CD30+ cells, leading to a diagnosis of CD30+ LCL.

Findings:

• This represents the first reported case of CD30+ LCL initially manifesting as a solitary scrotal nodule.
• The diagnosis required thorough systemic evaluation to rule out other conditions.

Implications:

• The findings highlight the importance of considering CD30+ LCL in the differential diagnosis of unusual skin lesions.
• Accurate diagnosis, including immunohistological studies and systemic staging, is vital to avoid over-treatment of this indolent lymphoma with a good prognosis.