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Related Experiment Video

Updated: Jun 17, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Oncocytic choroid plexus carcinoma: case report.

A Sav1, B W Scheithauer, C A Mazzola

  • 1Department of Pathology, Mayo Clinic, Rochester, Minnesota, USA.

Clinical Neuropathology
|December 31, 2009
PubMed
Summary

This study details a rare choroid plexus carcinoma in a child, featuring significant oncocytic changes. The tumor recurred as a non-oncocytic form, highlighting a unique presentation of this rare brain tumor.

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Area of Science:

  • Neuro-oncology
  • Pediatric Pathology
  • Surgical Neurology

Background:

  • Choroid plexus tumors are rare intraventricular neoplasms, with choroid plexus carcinoma (CPC) being the most aggressive subtype.
  • Oncocytic transformation is a recognized phenomenon in various neoplasms but has not been previously described in CPC.

Observation:

  • A 13-month-old female presented with rapid neurological decline due to a hemorrhagic intracranial tumor.
  • Imaging revealed a large, vascular left lateral ventricular mass causing impending herniation.
  • Histopathological examination showed a WHO Grade III CPC with extensive oncocytic features.

Findings:

  • The tumor exhibited distinct areas: a minor component of classical CPC with high mitotic activity and MIB-1 index, and a major component of malignant oncocytes with low proliferative activity.

Related Experiment Videos

Last Updated: Jun 17, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

  • Despite near-total resection, the tumor recurred after one year, entirely as non-oncocytic CPC.
  • This represents the first reported case of CPC with extensive oncocytic transformation.

    • Implications:

    • The biological behavior and clinical significance of oncocytic transformation in CPC require further investigation.
    • Understanding this rare variant may impact diagnostic criteria and therapeutic strategies for pediatric brain tumors.
    • The distinct proliferative indices between the oncocyti c and non-oncocyti c components suggest potential differences in treatment response.