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Updated: Jun 17, 2026

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Microbubble characterization through acoustically induced deflation.

Francesco Guidi1, Hendrik J Vos, Riccardo Mori

  • 1Department of Electronics and Telecommunications, Universita degli Studi di Firenze, Florence, Italy. Francesco.Guidi@unifi.it

IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
|December 31, 2009
PubMed
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This study investigated ultrasound contrast agent microbubble behavior using combined acoustic and optical methods. Smaller microbubbles deflated to a stable size, revealing insights into their acoustic response and damping characteristics.

Area of Science:

  • Acoustic characterization of microbubbles
  • Biomedical acoustics
  • Ultrasound contrast agents

Background:

  • Ultrasound contrast agents (UCAs) are polydisperse, complicating acoustic characterization of individual microbubbles.
  • Current acoustic characterization often analyzes full UCA populations, masking individual bubble behaviors.

Purpose of the Study:

  • To investigate the acoustic response of isolated lipid-shelled microbubbles to low-pressure ultrasound.
  • To understand the deflation dynamics and resonant properties of individual microbubbles.

Main Methods:

  • Combined acoustic and optical methods using a microscope and fast camera.
  • Ultrasound tone bursts at low peak negative pressures (49 and 62 kPa).
  • Cyclic frequency changes (2-4 MHz) during pulse repetition intervals to measure individual bubble behavior.

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Main Results:

  • Microbubbles larger than 3 µm showed no size reduction; smaller bubbles deflated to ~1.4 µm.
  • Backscattered pressure amplitude decreased from 5 Pa to 1 Pa at 2 MHz during deflation.
  • Resonant radius varied with excitation frequency, and the relative phase shift exceeded π/2.

Conclusions:

  • Individual microbubble acoustic behavior, including deflation and resonance, can be precisely measured.
  • Deflation dynamics and resonant radius provide insights into microbubble damping.
  • An undamped natural frequency of 2 MHz was estimated for a 1.7 µm microbubble.