Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hydrogen Bonds00:26

Hydrogen Bonds

Hydrogen BondsHydrogen bonds are weak attractions between atoms that have formed other chemical bonds. One of these atoms is electronegative, like oxygen, and has a partial negative charge. The other is a hydrogen atom that has bonded with another electronegative atom and has a partial positive charge.Hydrogen Bonds Control the World!Because hydrogen has very weak electronegativity when it binds with a strongly electronegative atom, such as oxygen or nitrogen, electrons in the bond are...
Hydrogen Bonds01:04

Hydrogen Bonds

A hydrogen bond is formed when a weakly positive hydrogen atom already bonded to one electronegative atom (for example, the oxygen in the water molecule) is attracted to another electronegative atom from another polar molecule, such as water (H2O), hydrogen fluoride (HF), or ammonia (NH3). The huge electronegativity difference between the H atom (2.1) and the atom to which it is bonded (4.0 for an F atom, 3.5 for an O atom, or 3.0 for an N atom), combined with the very small size of an H atom...
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue, improving...
Microbial Interactions: Mutualism01:25

Microbial Interactions: Mutualism

Mutualism is a symbiotic interaction in which all participating organisms benefit. These relationships can be obligate or facultative and are fundamental to ecosystem functions across diverse biological systems.Plant–Fungi MutualismOne well-known example is the association between plant roots and mycorrhizal fungi, such as Rhizophagus species. The fungal hyphae penetrate the root hairs and the epidermis, forming an extensive hyphal network that establishes a symbiotic association. Through this...
Reduction of Alkenes: Catalytic Hydrogenation02:13

Reduction of Alkenes: Catalytic Hydrogenation

Alkenes undergo reduction by the addition of molecular hydrogen to give alkanes. Because the process generally occurs in the presence of a transition-metal catalyst, the reaction is called catalytic hydrogenation.
Metals like palladium, platinum, and nickel are commonly used in their solid forms — fine powder on an inert surface. As these catalysts remain insoluble in the reaction mixture, they are referred to as heterogeneous catalysts.
The hydrogenation process takes place on the surface of...
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation02:17

Reduction of Alkenes: Asymmetric Catalytic Hydrogenation

Catalytic hydrogenation of alkenes is a transition-metal catalyzed reduction of the double bond using molecular hydrogen to give alkanes. The mode of hydrogen addition follows syn stereochemistry.
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring the effect of carbon support dimensionality on FeN<sub>4</sub>-based acetone sensors.

Biophysical chemistry·2026
Same author

A novel two-hit murine model of viral-primed sepsis-associated acute kidney injury.

American journal of physiology. Renal physiology·2026
Same author

Understanding the synergistic role of Ni/Pt doping and γ-Al<sub>2</sub>O<sub>3</sub> support in tuning CO<sub>2</sub> adsorption and activation on Cu<sub>13</sub> nanoclusters.

Journal of molecular graphics & modelling·2026
Same author

Glucose selectively drives a rapid oxidative burst and immunometabolic reprogramming in human neutrophils during <i>Mycobacterium tuberculosis</i> infection.

bioRxiv : the preprint server for biology·2026
Same author

Loss of proximal tubule lactate dehydrogenase A exacerbates nephrotoxic acute kidney injury through metabolic dysregulation.

American journal of physiology. Renal physiology·2026
Same author

Design, synthesis and evaluation of novel BRD4 and RIPK3 dual inhibitors as potential anti-inflammatory agents and antidotes for arsenicals.

Bioorganic & medicinal chemistry letters·2026

Related Experiment Video

Updated: Jun 17, 2026

Hydrogen Production and Utilization in a Membrane Reactor
10:00

Hydrogen Production and Utilization in a Membrane Reactor

Published on: March 10, 2023

Hydrogen: another gas with therapeutic potential.

James F George1, Anupam Agarwal

  • 1[1] Department of Surgery, Division of Cardiothoracic Surgery, University of Alabama at Birmingham, 1900 University Boulevard, Birmingham, AL 35294, USA.

Kidney International
|December 31, 2009
PubMed
Summary

Molecular hydrogen shows promise in treating chronic allograft nephropathy (CAN) in kidney transplant rats. Supplementing drinking water with hydrogen reduced CAN severity and improved graft survival by lowering reactive oxygen species.

More Related Videos

In Situ High Pressure Hydrogen Tribological Testing of Common Polymer Materials Used in the Hydrogen Delivery Infrastructure
10:01

In Situ High Pressure Hydrogen Tribological Testing of Common Polymer Materials Used in the Hydrogen Delivery Infrastructure

Published on: March 31, 2018

A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria
03:55

A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria

Published on: June 27, 2022

Related Experiment Videos

Last Updated: Jun 17, 2026

Hydrogen Production and Utilization in a Membrane Reactor
10:00

Hydrogen Production and Utilization in a Membrane Reactor

Published on: March 10, 2023

In Situ High Pressure Hydrogen Tribological Testing of Common Polymer Materials Used in the Hydrogen Delivery Infrastructure
10:01

In Situ High Pressure Hydrogen Tribological Testing of Common Polymer Materials Used in the Hydrogen Delivery Infrastructure

Published on: March 31, 2018

A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria
03:55

A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria

Published on: June 27, 2022

Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Biomedical Research

Background:

  • Chronic allograft nephropathy (CAN) is a significant cause of kidney transplant failure.
  • Current treatments for CAN are limited, necessitating novel therapeutic strategies.
  • Molecular hydrogen (H2) is an emerging therapeutic gas with known antioxidant properties.

Discussion:

  • This study investigates H2 as a potential treatment for CAN in a preclinical rat model.
  • Results indicate that H2 administration via drinking water ameliorates CAN.
  • The therapeutic effect is potentially mediated by the reduction of reactive oxygen species (ROS).

Key Insights:

  • Oral H2 supplementation significantly reduces the severity of chronic allograft nephropathy in rats.
  • H2 treatment leads to increased survival rates of kidney allografts.
  • Evidence suggests ROS scavenging is a primary mechanism underlying H2's protective effects.

Outlook:

  • Further research is warranted to explore H2 therapy for human kidney transplantation.
  • Investigating optimal H2 dosage and delivery methods for clinical application.
  • Exploring H2's potential in other transplant settings and related fibrotic diseases.