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Published on: November 21, 2013
Olanzapine induced tardive dystonia
1Department of Psychiatry, G. B. Pant Hospital and Maulana Azad Medical College, New Delhi, India.
Indian Journal of Pharmacology
|December 31, 2009
Summary
Atypical antipsychotics like olanzapine may still cause tardive dystonia (TD), a movement disorder. This case highlights the risk of TD even with newer schizophrenia treatments.
Area of Science:
- Psychopharmacology
- Neurology
- Movement Disorders
Background:
- Atypical antipsychotics were developed to treat schizophrenia with fewer side effects than typical antipsychotics.
- These newer agents were expected to have a lower risk of extrapyramidal symptoms, including tardive movements.
- Olanzapine, a second-generation antipsychotic, acts on serotonin and dopamine receptors.
Purpose of the Study:
- To report a case of tardive dystonia (TD) in a patient treated with olanzapine.
- To contribute to the limited literature on olanzapine-induced TD.
Main Methods:
- Case report of a male patient diagnosed with schizophrenia.
- Clinical observation of adverse effects during olanzapine treatment.
Main Results:
- The patient developed tardive dystonia (TD) after 15 months of olanzapine therapy.
- This case adds to the few documented instances of olanzapine-induced TD.
Conclusions:
- Olanzapine, despite being an atypical antipsychotic, can induce tardive dystonia (TD).
- Clinicians should remain vigilant for movement disorders in patients on olanzapine.
- Further research is needed to understand the risk factors and mechanisms of olanzapine-induced TD.
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