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Emergency therapeutic leukapheresis in a case of acute myeloid leukemia M5

Sudha Ranganathan1, Shyamala Sesikeran, Vineet Gupta

  • 1Apollo Hospital, Hyderabad.

Asian Journal of Transfusion Science
|December 31, 2009
PubMed

Insights

Emergency leukapheresis effectively reduced white blood cell (WBC) counts in a patient with acute myeloid leukemia (AML M5). This vital procedure enabled the prompt initiation of life-saving cytotoxic therapy.

Area of Science:

  • Hematology
  • Oncology
  • Medical Technology

Background:

  • Cell separators are standard in India for procedures like plateletpheresis and stem cell collection.
  • Therapeutic leukapheresis, especially in emergencies, is rarely documented.

Observation:

  • A 53-year-old male with acute myeloid leukemia subtype M5 (AML M5) presented with hyperleukocytosis.
  • The patient required an emergency leukapheresis procedure due to extremely high white blood cell (WBC) counts.

Findings:

  • Two sessions of therapeutic leukapheresis were performed.
  • A significant reduction of 85% in WBC count was achieved post-procedure.

Implications:

  • Emergency leukapheresis proved crucial for managing hyperleukocytosis in AML M5.
  • This intervention facilitated the timely commencement of essential cytotoxic chemotherapy.
Keywords:
Emergencyhyperleukocytosisleukapheresis

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