Related Experiment Video

Updated: Jun 12, 2026

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay (PCA) in Living Cells
08:38

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay (PCA) in Living Cells

Published on: March 3, 2015

Genome-wide association data reveal a global map of genetic interactions among protein complexes

Gregory Hannum1, Rohith Srivas, Aude Guénolé

  • 1Department of Bioengineering, University of California San Diego, La Jolla, California, USA.

Plos Genetics
|December 31, 2009
PubMed

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Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
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