Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Cell Death01:30

Overview of Cell Death

Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
Autophagic Cell Death01:18

Autophagic Cell Death

Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and pro-apoptotic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retinoic acid regulates the proliferation, differentiation, and cell death of limb skeletal progenitors, contributing to establish the size and identity of the digits.

EvoDevo·2025
Same author

Lysosomes, caspase-mediated apoptosis, and cytoplasmic activation of P21, but not cell senescence, participate in a redundant fashion in embryonic morphogenetic cell death.

Cell death & disease·2023
Same author

Modeling the Differentiation of Embryonic Limb Chondroprogenitors by Cell Death and Cell Senescence in High Density Micromass Cultures and Their Regulation by FGF Signaling.

Cells·2023
Same author

Regulation of Developmental Cell Death in the Animal Kingdom: A Critical Analysis of Epigenetic versus Genetic Factors.

International journal of molecular sciences·2022
Same author

Histone Epigenetic Signatures in Embryonic Limb Interdigital Cells Fated to Die.

Cells·2021
Same author

Transforming growth factor beta signaling: The master sculptor of fingers.

Developmental dynamics : an official publication of the American Association of Anatomists·2021
Same journal

Mitochondrial dysfunction and cellular senescence drive accelerated gestational aging in spontaneous preterm birth: a narrative review.

Apoptosis : an international journal on programmed cell death·2026
Same journal

Taginostat, a new quinolone-based HDAC6 inhibitor, promotes apoptosis of chronic lymphocytic leukemia cells in vitro and in vivo by activating STAT4.

Apoptosis : an international journal on programmed cell death·2026
Same journal

Correction: Non-canonical cell death in neurodegeneration: emerging mechanisms and therapeutic Frontiers.

Apoptosis : an international journal on programmed cell death·2026
Same journal

Targeting the fibrosis-inflammation-oxidative stress axis: multifaceted mechanisms of salidroside in chronic organ fibrosis.

Apoptosis : an international journal on programmed cell death·2026
Same journal

Microglial tunneling nanotubes: an intercellular transfer facilitating mitochondrial dysfunction and neuroinflammation in experimental cerebral malaria.

Apoptosis : an international journal on programmed cell death·2026
Same journal

Copper dysregulation in cardiometabolic disease: copper deficiency versus cuproptosis.

Apoptosis : an international journal on programmed cell death·2026
See all related articles

Related Experiment Video

Updated: Jun 17, 2026

Adult Mouse Digit Amputation and Regeneration: A Simple Model to Investigate Mammalian Blastema Formation and Intramembranous Ossification
09:17

Adult Mouse Digit Amputation and Regeneration: A Simple Model to Investigate Mammalian Blastema Formation and Intramembranous Ossification

Published on: July 12, 2019

Sculpturing digit shape by cell death.

Juan A Montero1, Juan M Hurlé

  • 1Departamento de Anatomía y Biología Celular, Universidad de Cantabria/IFIMAV, Santander, Spain.

Apoptosis : an International Journal on Programmed Cell Death
|December 31, 2009
PubMed
Summary
This summary is machine-generated.

Physiological cell death is crucial for embryonic development, particularly in digit formation. This study explores alternative cell death mechanisms beyond apoptosis in vertebrate interdigital tissues.

More Related Videos

Assessing Cell Viability and Death in 3D Spheroid Cultures of Cancer Cells
10:33

Assessing Cell Viability and Death in 3D Spheroid Cultures of Cancer Cells

Published on: June 16, 2019

3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects
08:15

3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects

Published on: August 4, 2020

Related Experiment Videos

Last Updated: Jun 17, 2026

Adult Mouse Digit Amputation and Regeneration: A Simple Model to Investigate Mammalian Blastema Formation and Intramembranous Ossification
09:17

Adult Mouse Digit Amputation and Regeneration: A Simple Model to Investigate Mammalian Blastema Formation and Intramembranous Ossification

Published on: July 12, 2019

Assessing Cell Viability and Death in 3D Spheroid Cultures of Cancer Cells
10:33

Assessing Cell Viability and Death in 3D Spheroid Cultures of Cancer Cells

Published on: June 16, 2019

3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects
08:15

3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects

Published on: August 4, 2020

Area of Science:

  • Developmental Biology
  • Cell Death Research
  • Morphogenesis

Background:

  • Physiological cell death is essential for tissue and organ development in multicellular organisms.
  • Interdigital cell death in vertebrate embryos is a key model for understanding digit morphogenesis.
  • Apoptosis, involving caspases, is the primary known pathway for programmed cell death.

Purpose of the Study:

  • To investigate the mechanisms of physiological cell death during vertebrate embryonic interdigital tissue development.
  • To explore alternative or complementary cell death pathways beyond classical apoptosis.
  • To understand the role of cell death in digit morphogenesis and potential implications for syndactyly.

Main Methods:

  • Histological analysis of dying cells in embryonic interdigital tissues.
  • Review of existing literature on caspase loss-of-function experiments (KO mice and chickens).
  • Discussion of cell death via autophagy as a potential alternative pathway.

Main Results:

  • Loss-of-function experiments for caspases have not resulted in the expected syndactyly phenotype.
  • Histological analysis reveals the simultaneous occurrence of different cell death types in interdigital tissues.
  • Findings suggest caspase-independent mechanisms contribute to physiological interdigital cell death.

Conclusions:

  • Classical apoptosis may not be the sole mechanism driving physiological interdigital cell death.
  • Alternative cell death pathways, potentially including autophagy, are critical for vertebrate morphogenesis.
  • Further characterization of these alternative pathways is necessary to fully explain embryonic development.