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Enhancing medication adherence in patients with bipolar disorder
Lesley Berk1, Karen T Hallam, Francesc Colom
1University of Melbourne, Victoria, Australia.
Human Psychopharmacology
|December 31, 2009
Summary
Improving medication adherence in bipolar disorder is crucial for treatment success. Psychosocial interventions, particularly psycho-education, show promise but require larger trials for real-world application.
Area of Science:
- Psychiatry
- Pharmacology
- Psychosocial Interventions
Background:
- Medication adherence significantly impacts treatment outcomes in bipolar disorder.
- Non-adherence contributes to the efficacy-effectiveness gap in bipolar disorder management.
Purpose of the Study:
- To examine challenges in improving medication adherence for bipolar disorder patients.
- To identify future directions for psychosocial interventions targeting adherence.
Main Methods:
- Literature search of articles from 1996-2008 in Medline, Web of Science, CINAHL PLUS, and PsychINFO.
- Keywords included adherence, compliance, alliance, risk factors, psychosocial interventions, and psycho-education.
Main Results:
- Challenges in defining and measuring non-adherence exist, alongside various risk factors.
- Small studies suggest psycho-education can improve knowledge and adherence, but large trials are needed.
- Larger trials indicate psychosocial interventions targeting adherence as a secondary outcome can improve results.
Conclusions:
- Enhancing treatment adherence is a vital adjunct to pharmacotherapy in bipolar disorder.
- Refining the concept of non-adherence and tailoring psycho-education for subgroups is possible.
- Large-scale trials of condensed interventions are necessary to inform clinical practice.
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