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Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Overview of Fatty Acid Metabolism01:28

Overview of Fatty Acid Metabolism

Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Structure of Lipids03:38

Structure of Lipids

Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic birds and...
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis directly...
Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis directly...

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Updated: Jun 17, 2026

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas
03:07

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

Published on: November 11, 2025

Fatty acids and obesity.

M Bermúdez Menéndez de la Granda1, A J Sinclair

  • 1University Hospital of Getafe, Madrid, Spain.

Current Pharmaceutical Design
|January 1, 2010
PubMed
Summary
This summary is machine-generated.

Obesity increases the risk of chronic diseases. Unsaturated fatty acids, like omega-3 and omega-6, show potential in counteracting obesity

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Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide
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Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide

Published on: May 12, 2023

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Last Updated: Jun 17, 2026

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas
03:07

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

Published on: November 11, 2025

Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide
07:34

Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide

Published on: May 12, 2023

Area of Science:

  • Nutrition science
  • Public health
  • Cardiovascular research

Background:

  • Obesity is a growing global health concern, linked to increased risks of chronic diseases such as hypertension, diabetes, cardiovascular disease, stroke, and cancer.
  • Obese individuals face a significantly higher risk of premature death, mainly due to associations with type 2 diabetes and coronary heart disease (CHD).
  • Scientific interest in the health impacts of omega-3 and omega-6 fatty acids has surged over the last two decades.

Purpose of the Study:

  • To explore the cardiovascular benefits of omega-3 and omega-6 fatty acids.
  • To investigate the potential of unsaturated fatty acids in mitigating the adverse effects of obesity.
  • To review existing epidemiological and experimental evidence on fatty acids and cardiovascular health.

Main Methods:

  • Review of epidemiological and experimental studies on omega-3 and omega-6 fatty acids.
  • Identification of key fatty acids: eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), alpha-linolenic acid (ALA), linoleic acid (LA), and conjugated linoleic acid (CLA).
  • Analysis of dietary sources for these fatty acids.

Main Results:

  • Omega-3 fatty acids (EPA, DHA, ALA) found in fish, oils, seeds, and vegetables are associated with cardiovascular benefits.
  • Omega-6 fatty acids (LA) are present in grains, meats, and plant seeds.
  • Conjugated linoleic acid (CLA) isomers show promise for specific cardiovascular benefits.

Conclusions:

  • Unsaturated fatty acids, including omega-3 and omega-6, play a crucial role in human health.
  • The potential of these fatty acids to counteract obesity-related health issues warrants further in-depth investigation.
  • Further research is needed to fully understand and leverage the cardiovascular benefits of various unsaturated fatty acids.