Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...
Hyperglycemia01:29

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Kidney Transplant Recipient With Coronavirus Disease 2019: Utility of a Prognostication Score.

Transplantation proceedings·2020
Same author

The effect of peri-transplant plasmapheresis in the prevention of recurrent FSGS.

Pediatric transplantation·2018
Same author

Genome-wide association study identifies the common variants in CYP3A4 and CYP3A5 responsible for variation in tacrolimus trough concentration in Caucasian kidney transplant recipients.

The pharmacogenomics journal·2017
Same author

Renal Consequences of Diabetes After Kidney Donation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2017
Same author

The impact of recipient BKV shedding before transplant on BKV viruria, DNAemia, and nephropathy post-transplant: A prospective study.

Pediatric transplantation·2017
Same author

The Living Donor Collective: A Scientific Registry for Living Donors.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2017
Same journal

Alpha-Gal Syndrome: Unrecognized Risks of a Tick-Bite-Associated Allergy in Transplantation and Cellular Therapy.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

Comment on "Role of social determinants and outcomes of patients with alcohol-associated liver disease referred for early liver transplantation: A multicenter analysis".

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

Ebola disease caused by Bundibugyo virus, Democratic Republic of the Congo & Uganda.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

Donor Acute Kidney Injury Is Not Associated With Inferior Outcomes After Simultaneous Pancreas-Kidney Transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

Human Biopsy-Defined IRI-Selective Reperfusion Signature Prioritizes Reperfusion-Timed MEK Inhibition After DCD Liver Transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

OPERATIONAL TOLERANCE FOLLOWING INTESTINAL TRANSPLANTATION: A CASE REPORT WITH COMPREHENSIVE IMMUNE FOLLOW-UP FROM TRANSPLANT DAY TO THREE YEARS POST-IMMUNOSUPPRESSION WITHDRAWAL.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
See all related articles

Related Experiment Video

Updated: Jun 17, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

Diabetes after kidney donation.

H N Ibrahim1, A Kukla, G Cordner

  • 1Department of Medicine, University of Minnesota, Minneapolis, MN, USA. ibrah007@umn.edu

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|January 1, 2010
PubMed
Summary
This summary is machine-generated.

Kidney donors face risks for type 2 diabetes mellitus (T2DM), similar to the general population. Developing T2DM post-donation was linked to recipient

More Related Videos

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice
10:43

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice

Published on: October 31, 2007

Related Experiment Videos

Last Updated: Jun 17, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice
10:43

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice

Published on: October 31, 2007

Area of Science:

  • Nephrology
  • Endocrinology
  • Transplantation

Background:

  • Kidney donors share general population risks for type 2 diabetes mellitus (T2DM).
  • The long-term outcomes for kidney donors who develop T2DM remain understudied.
  • Understanding T2DM development in kidney donors is crucial for post-donation care.

Purpose of the Study:

  • To investigate the incidence and risk factors for type 2 diabetes mellitus (T2DM) in kidney donors.
  • To compare the clinical course of kidney donors with T2DM to non-diabetic controls.
  • To assess the impact of T2DM on kidney function (eGFR) in kidney donors.

Main Methods:

  • A survey was conducted among 3777 kidney donors to identify T2DM development.
  • Multivariable analysis identified risk factors associated with T2DM development.
  • Diabetic donors were compared to matched non-diabetic controls regarding hypertension, proteinuria, and serum creatinine.
  • Estimated glomerular filtration rate (eGFR) change was analyzed in diabetic and non-diabetic donors.

Main Results:

  • 154 out of 2954 respondents developed T2DM, a median of 17.7 years post-donation.
  • Multivariable risk factors for T2DM included recipient's type 1 diabetes, male gender, and pre-donation BMI >30 kg/m².
  • Diabetic donors exhibited higher rates of hypertension (70.8% vs. 36.2%) and proteinuria (18.8% vs. 3.9%) compared to controls.
  • Short-term eGFR decline was comparable across diabetic donors and matched non-diabetic controls.

Conclusions:

  • Risk factors for T2DM in kidney donors mirror those in the general population.
  • Carefully screened kidney donors who develop T2DM do not appear to experience accelerated diabetic kidney disease in the short term.
  • These findings support continued careful screening and monitoring of kidney donors.