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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Cross-reactivity00:42

Cross-reactivity

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Related Experiment Video

Updated: Jun 17, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Food allergy.

Scott H Sicherer1, Hugh A Sampson

  • 1Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029-6574, USA. scott.sicherer@mssm.edu

The Journal of Allergy and Clinical Immunology
|January 1, 2010
PubMed
Summary
This summary is machine-generated.

Food allergies, involving IgE-mediated and non-IgE-mediated mechanisms, affect millions globally. Diagnosis requires careful evaluation, and management focuses on allergen avoidance and prompt treatment of reactions.

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Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
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Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

Area of Science:

  • Immunology
  • Allergy and Immunology

Background:

  • Adverse immune responses to foods are increasingly prevalent, affecting both children and adults.
  • Food allergies manifest with diverse symptoms across skin, gastrointestinal, and respiratory systems.
  • Mechanisms include both immunoglobulin E (IgE)-mediated and non-IgE-mediated (cellular) pathways.

Purpose of the Study:

  • To review the current understanding of food allergy.
  • To discuss diagnostic challenges and emerging methods.
  • To outline current and investigational management strategies.

Main Methods:

  • Literature review of food allergy mechanisms, diagnosis, and management.
  • Analysis of diagnostic criteria, including IgE testing and oral food challenges.
  • Overview of current therapeutic approaches and novel treatment research.

Main Results:

  • Food allergy prevalence is significant and rising.
  • Diagnosis is complex, as IgE sensitization does not always correlate with clinical allergy.
  • Current management relies on allergen avoidance and emergency treatment, with immunotherapy and other novel therapies under investigation.

Conclusions:

  • Accurate diagnosis of food allergy is crucial and often requires a multi-faceted approach.
  • Effective management strategies are evolving, with a focus on improved diagnostics and novel therapeutics.
  • Further research into immune responses and allergen-specific treatments holds promise for better patient outcomes.