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Related Concept Videos

Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this principle...

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Related Experiment Video

Updated: Jun 17, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Quantitative diffusion tensor deterministic and probabilistic fiber tractography in relapsing-remitting multiple

Bing Hu1, Binbin Ye, Yang Yang

  • 1Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Road Tianhe 600, 510630 Guangdong, Guangzhou, China.

European Journal of Radiology
|January 1, 2010
PubMed
Summary
This summary is machine-generated.

Quantitative fiber tractography reveals white matter changes in relapsing-remitting multiple sclerosis (RRMS). These changes correlate with clinical disability, as measured by the Expanded Disability Status Scale (EDSS).

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Last Updated: Jun 17, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

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Published on: July 28, 2013

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DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions
10:05

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

Published on: August 26, 2014

Area of Science:

  • Neuroimaging
  • Neurology
  • Medical Physics

Background:

  • Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system.
  • Relapsing-remitting multiple sclerosis (RRMS) is the most common form of MS.
  • White matter tract integrity is crucial for neurological function.

Purpose of the Study:

  • To investigate quantitative fiber tractography variations in RRMS patients.
  • To assess the correlation between quantitative fiber tractography and clinical disability (EDSS).

Main Methods:

  • Diffusion tensor MR imaging was performed on 28 RRMS patients and 28 healthy controls.
  • Quantitative deterministic and probabilistic fiber tractography were generated.
  • Tracked lines and fiber density were quantified and compared between groups.

Main Results:

  • RRMS patients showed significantly reduced tracked lines and fiber density compared to controls (P<.001).
  • Both measures demonstrated a significant negative correlation with EDSS scores in RRMS patients (P<.001).
  • Fiber tract disruptions were visually confirmed by tractography.

Conclusions:

  • Quantitative diffusion tensor fiber tractography can detect white matter alterations in RRMS.
  • These detected changes correlate with the clinical impairment experienced by RRMS patients.